Forkhead Box Protein 3: Difference between revisions
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The interaction of FOXP3 with NFAT1 and the FOXP3-NFAT1 target sequences found in IL-2 has been investigated extensively. The <scene name='Forkhead_Box_Protein_3/Foxp3_monomer/1'>Forkhead domain of FOXP3</scene> appears to form a <scene name='Forkhead_Box_Protein_3/Foxp3_dimer/1'>domain swapped dimer</scene> with a <scene name='Forkhead_Box_Protein_3/Nfat_dimer/2'>dimerized rel homology region (RHR) of NFAT1</scene> and two unique <scene name='Forkhead_Box_Protein_3/Oligonucleotides/2'>oligonucleotides</scene>, each containing distinct FOXP sites.<ref name="Chen">PMID: 21458306</ref> | The interaction of FOXP3 with NFAT1 and the FOXP3-NFAT1 target sequences found in IL-2 has been investigated extensively. The <scene name='Forkhead_Box_Protein_3/Foxp3_monomer/1'>Forkhead domain of FOXP3</scene> appears to form a <scene name='Forkhead_Box_Protein_3/Foxp3_dimer/1'>domain swapped dimer</scene> with a <scene name='Forkhead_Box_Protein_3/Nfat_dimer/2'>dimerized rel homology region (RHR) of NFAT1</scene> and two unique <scene name='Forkhead_Box_Protein_3/Oligonucleotides/2'>oligonucleotides</scene>, each containing distinct FOXP sites.<ref name="Chen">PMID: 21458306</ref> | ||
Each domain-swapped dimer of FOXP3 makes extensive interactions with NFAT1 involving residues Thr359, Asn361, His365, Glu399, and Glu401 of FOXP3, among others, which were critical in the [[FOXP2]]-NFAT1 interaction.<ref name="Chen"/> | |||
<ref name="Chen"/> | <ref name="Chen"/> | ||