1n1f: Difference between revisions
New page: left|200px<br /> <applet load="1n1f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n1f, resolution 1.95Å" /> '''Crystal Structure o... |
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[[Image:1n1f. | [[Image:1n1f.jpg|left|200px]]<br /><applet load="1n1f" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''Crystal Structure of Human Interleukin-19'''<br /> | '''Crystal Structure of Human Interleukin-19'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1N1F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1N1F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1F OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: interleukin]] | [[Category: interleukin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:26:30 2008'' | ||
Revision as of 17:26, 15 February 2008
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Crystal Structure of Human Interleukin-19
OverviewOverview
Interleukin-19 (IL-19) is a novel cytokine that was initially identified, during a sequence data base search aimed at finding potential IL-10, homologs. IL-19 shares a receptor complex with IL-20, indicating that the, biological activities of these two cytokines overlap and that both may, play an important role in regulating development and proper functioning of, the skin. We determined the crystal structure of human recombinant IL-19, and refined it at 1.95-A resolution to an R-factor of 0.157. Unlike IL-10, which forms an intercalated dimer, the molecule of IL-19 is a monomer made, of seven amphipathic helices, A-G, creating a unique helical bundle. On, the basis of the observed structure, we propose that IL-19, IL-20, and, other putative members of the proposed IL-10 family together form a, distinct subfamily of helical cytokines.
About this StructureAbout this Structure
1N1F is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of interleukin-19 defines a new subfamily of helical cytokines., Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A, J Biol Chem. 2003 Jan 31;278(5):3308-13. Epub 2002 Oct 25. PMID:12403790
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