1mco: Difference between revisions
New page: left|200px<br /> <applet load="1mco" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mco, resolution 3.2Å" /> '''THREE-DIMENSIONAL ST... |
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'''THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION'''<br /> | '''THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1MCO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1MCO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MCO OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:23:32 2008'' | ||
Revision as of 17:23, 15 February 2008
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THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION
OverviewOverview
X-ray analysis at 3.2-A resolution revealed that the Mcg IgG1 (lambda, chain) immunoglobulin is a compact T-shaped molecule. Because of the hinge, deletion, the Fc fragment lobe is pulled tightly upward into the junction, of the Fab arms. Along the molecular twofold axis, the Fab arms are joined, by an interchain disulfide bond between the two light chains. The antigen, combining sites consist of large irregular cavities at the tips of the Fab, regions. Potential complement (C1q) binding sites on Fc are sterically, shielded by the Fab arms, but putative attachment sites are accessible for, docking with the FcRI receptor on human monocytes and with protein A of, Staphylococcus aureus.
About this StructureAbout this Structure
1MCO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Three-dimensional structure of a human immunoglobulin with a hinge deletion., Guddat LW, Herron JN, Edmundson AB, Proc Natl Acad Sci U S A. 1993 May 1;90(9):4271-5. PMID:8483943
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