Interferon: Difference between revisions

Revision as of 04:05, 22 April 2012

Interferon-β

is a protein growth factor that stimulates an antiviral defense. Its encoding gene is one of only two known vertebrate structural genes that lacks introns.^[1]

Interferon-β is a relatively simple biological response modifier, with several . It consists of five , as well as multiple interconnecting . Helices A, B and D run , and helices C and E run to the other three helices, but to one another. Helix A consists of residues 6-23; Helix B consists of residues 49-65; Helix C consists of residues 77-91; Helix D consists of residues 112-131; and Helix E consists of residues 135-155.^[2]^[3]

Interferon-α

Interferon-γ

Click on the green links to the left to view the structural aspects of interferons. PDB ID: 2hym)

Drag the structure with the mouse to rotate

A comparative representation of three interferonsA comparative representation of three interferons

Synchronize the three applets showing interferons alpha, beta, and gamma by clicking the checkbox

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Kirsten Eldredge, Michal Harel, Jaime Prilusky, Alexander Berchansky, Karl Oberholser, Joel L. Sussman

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!--
+<StructureSection load='2hym' size='500' side='right' caption='Click on the green links to the left to view the structural aspects of interferons. PDB ID: [[2hym]])' scene='Interferons/Interferonaandreceptor/2'>
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+==Interferon-β==
-Or use the four-green-boxes-button to insert scrollable text adjacent
+<scene name='Multiple_sclerosis/Interferon_beta/9'>Interferon-β</scene> is a protein growth factor that stimulates an antiviral defense. Its encoding gene is one of only two known vertebrate structural genes that lacks introns.<ref name="Biochem Text">Voet, D., Voet, J.G., and C. Pratt. ''Fundamentals of Biochemistry'' 3rd Edition. Hoboken, NJ: John Wiley and Sons, 2008. Print.</ref>
-to a Jmol applet. Check out the other buttons as well!
--->
+Interferon-β is a relatively simple biological response modifier, with several <scene name='Multiple_sclerosis/Interferon_beta_labeled/1'>identifiable regions</scene>. It consists of five <scene name='Multiple_sclerosis/Ifnb_helices_in_color/1'>alpha helices</scene>, as well as multiple interconnecting <scene name='Multiple_sclerosis/Interferon_beta_loops/2'>loop regions</scene>. Helices A, B and D run <scene name='Multiple_sclerosis/Ifnb_parallel_abd/3'>parallel to one another</scene>, and helices C and E run <scene name='Multiple_sclerosis/Ifnb_antiparallel/1'>anti-parallel</scene> to the other three helices, but <scene name='Multiple_sclerosis/Ifnb_antiparallel_ce/3'>parallel</scene> to one another. Helix A consists of residues 6-23; Helix B consists of residues 49-65; Helix C consists of residues 77-91; Helix D consists of residues 112-131; and Helix E consists of residues 135-155.<ref name="Structure Ifn B">PMID:20616576</ref><ref name="UniProt">http://www.uniprot.org/uniprot/P00784</ref>
+==Interferon-α==
+==Interferon-γ==
+</StructureSection>
 === A comparative representation of three interferons ===
 <center>
@@ Line 10: / Line 15: @@
 |<applet load='1ITF.pdb' name='A' size='300' frame='true' align='right' caption='Interferon Alpha' align='left' scene='Interferons/Ifn_alpha/4'/>
 |<applet load='1IFA.pdb' name='B' size='300' frame='true' align='right' caption='Interferon Beta' align='left' scene='Interferons/Interferon_beta/3'/>
-|<applet load='1HIG.pdb' name='Z' size='300' frame='true' align='right' caption='Interferon Gamma' align='left' scene='Interferons/Ifn_gamma/3'/>
+|<applet load='1HIG.pdb' name='Z' size='300' frame='true' align='right' caption='Interferon Gamma' align='left' scene='Interferons/Ifn_gamma/3'/>|
 |}