Flavin reductase: Difference between revisions
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'''Flavin reductase''' (FR) catalyzes the NADPH-dependent reduction of a variety of flavins such as riboflavin, FAD, FMN, biliverdin, methemoglobin and pyrroloquinoline quinone. FR converts reduced riboflavin to riboflavin and bilirubin to biliverdin. This reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia. FR is involved in heme catabolism | '''Flavin reductase''' (FR) catalyzes the NADPH-dependent reduction of a variety of flavins such as riboflavin, FAD, FMN, biliverdin, methemoglobin and pyrroloquinoline quinone. FR converts reduced riboflavin to riboflavin and bilirubin to biliverdin. This reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia. FR is involved in heme catabolism. | ||
==3D structures of flavin reductase== | ==3D structures of flavin reductase== | ||
Revision as of 11:39, 18 April 2012
Flavin reductase (FR) catalyzes the NADPH-dependent reduction of a variety of flavins such as riboflavin, FAD, FMN, biliverdin, methemoglobin and pyrroloquinoline quinone. FR converts reduced riboflavin to riboflavin and bilirubin to biliverdin. This reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia. FR is involved in heme catabolism.
3D structures of flavin reductase3D structures of flavin reductase
1qfj – FR – Escherichia coli
1bkj – VhFR + FMN – Vibrio harveyi
2bkj - VhFR + NAD + FMN
1hdo - hFR + NADP - human
1he2 - hFR + biliverdin IX α + NADP
1he3 - hFR + mesobiliverdin IV α + NADP
1he4 - hFR + FMN + NADP
1he5 - hFR + lumichrome + NADP
1rz0 – GtFR + FAD – Geobacillus thermoglucosidasius
1rz1 - GtFR + FAD + NAD
3pft - FR (mutant) + FMN – Mycobacterium goodii