1je6: Difference between revisions
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'''Structure of the MHC Class I Homolog MICB'''<br /> | '''Structure of the MHC Class I Homolog MICB'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1JE6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1JE6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JE6 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: t-cell]] | [[Category: t-cell]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:06:55 2008'' | ||
Revision as of 17:06, 15 February 2008
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Structure of the MHC Class I Homolog MICB
OverviewOverview
MIC-A and MIC-B are distant MHC class I homologs that serve as, stress-inducible Ags on epithelial and epithelially derived cells. They, are ligands for the widely expressed activating immunoreceptor NKG2D. To, define the structural and functional consequences of sequence differences, between MIC-A and MIC-B and between alleles of MIC-A and alleles of MIC-B, we determined the crystal structure of one allele of human MIC-B., Comparisons between the two previously reported MIC-A crystal structures, and the MIC-B crystal structure show that, as expected, MIC-B is very, similar in structure to MIC-A and likely interacts with NKG2D in an, analogous manner. The interdomain flexibility observed in the MIC-A, structures, a feature unique to MIC proteins among MHC class I proteins, and homologs, is also displayed by MIC-B, with an interdomain relationship, intermediate between the two examples of MIC-A structures. Mapping, sequence variations onto the structures of MIC-A and MIC-B reveals, patterns completely distinct from those displayed by classical MHC class I, proteins, with a number of substitutions falling on positions likely to, affect interactions with NKG2D, but with other positions lying distant, from the NKG2D binding sites or buried within the core of the proteins.
About this StructureAbout this Structure
1JE6 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D., Holmes MA, Li P, Petersdorf EW, Strong RK, J Immunol. 2002 Aug 1;169(3):1395-400. PMID:12133964
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