1j74: Difference between revisions
New page: left|200px<br /> <applet load="1j74" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j74, resolution 1.9Å" /> '''Crystal Structure of... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1j74. | [[Image:1j74.jpg|left|200px]]<br /><applet load="1j74" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1j74" size=" | |||
caption="1j74, resolution 1.9Å" /> | caption="1j74, resolution 1.9Å" /> | ||
'''Crystal Structure of Mms2'''<br /> | '''Crystal Structure of Mms2'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
1J74 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1J74 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J74 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 27: | Line 26: | ||
[[Category: uev]] | [[Category: uev]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:05:30 2008'' | ||
Revision as of 17:05, 15 February 2008
|
Crystal Structure of Mms2
OverviewOverview
The ubiquitin conjugating enzyme complex Mms2-Ubc13 plays a key role in, post-replicative DNA repair in yeast and the NF-kappaB signal transduction, pathway in humans. This complex assembles novel polyubiquitin chains onto, yet uncharacterized protein targets. Here we report the crystal structure, of a complex between hMms2 (Uev1) and hUbc13 at 1.85 A resolution and a, structure of free hMms2 at 1.9 A resolution. These structures reveal that, the hMms2 monomer undergoes a localized conformational change upon, interaction with hUbc13. The nature of the interface provides a physical, basis for the preference of Mms2 for Ubc13 as a partner over a variety of, other structurally similar ubiquitin-conjugating enzymes. The structure of, the hMms2-hUbc13 complex provides the conceptual foundation for, understanding the mechanism of Lys 63 multiubiquitin chain assembly and, for its interactions with the RING finger proteins Rad5 and Traf6.
About this StructureAbout this Structure
1J74 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13., Moraes TF, Edwards RA, McKenna S, Pastushok L, Xiao W, Glover JN, Ellison MJ, Nat Struct Biol. 2001 Aug;8(8):669-73. PMID:11473255
Page seeded by OCA on Fri Feb 15 16:05:30 2008