Multiple sclerosis: Difference between revisions
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Interferons alpha and beta interact with a receptor at the surface of <ref>[http://www.jbc.org/content/282/28/20045.full?sid=cbf08059-44d4-4957-8ea7-0351cab9c2ac] Samuel, C.E. "Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Inteferon Regulatory Factors." ''J Biol Chem'' 2007 282: 20045-20046. First Published on May 14, 2007, doi:10.1074/jbc.R700025200</ref> | Interferons alpha and beta interact with a receptor at the surface of <ref>[http://www.jbc.org/content/282/28/20045.full?sid=cbf08059-44d4-4957-8ea7-0351cab9c2ac] Samuel, C.E. "Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Inteferon Regulatory Factors." ''J Biol Chem'' 2007 282: 20045-20046. First Published on May 14, 2007, doi:10.1074/jbc.R700025200</ref> | ||
Interferon receptor | |||
<scene name='Multiple_sclerosis/Ifnr_domains_labeled/1'>Interferon receptor domains</scene> | <scene name='Multiple_sclerosis/Ifnr_domains_labeled/1'>Interferon receptor domains</scene> | ||
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<scene name='Multiple_sclerosis/Ifnr_c_domain_labeled/1'>C-domain, with one disulfide bond</scene> | <scene name='Multiple_sclerosis/Ifnr_c_domain_labeled/1'>C-domain, with one disulfide bond</scene> | ||
<scene name='Multiple_sclerosis/Ifnr_linker_region_labeled/1'>linker region</scene> | <scene name='Multiple_sclerosis/Ifnr_linker_region_labeled/1'>linker region</scene> | ||
<scene name='Multiple_sclerosis/Ifnr_termini_labeled/1'>termini regions, no structure.</scene> | <scene name='Multiple_sclerosis/Ifnr_termini_labeled/1'>termini regions, no structure.</scene> | ||
<scene name='Multiple_sclerosis/Ifnr_clash_n-c/1'>eight clashes between domains</scene><ref name="Interferon Receptor Structure">PMID:12842042</ref> | |||
Interferon receptor bound to interferon alpha | |||
<scene name='Multiple_sclerosis/Ifna/1'>Interferon alpha</scene> | |||
__NOTOC__ | __NOTOC__ | ||
</StructureSection> | </StructureSection> | ||
=== A comparative representation of the three forms of DNA === | |||
''Sources''<ref>http://203.129.231.23/indira/nacc/</ref> | |||
{| | |||
|<applet load='IfnA.pdb' name='A' size='400' frame='true' align='right' caption='Interferon Alpha' align='left' scene='Multiple_sclerosis/Ifna/1'/> | |||
|<applet load='IfnB.pdb' name='B' size='400' frame='true' align='right' caption='Interferon Beta' align='left' scene='Multiple_sclerosis/Interferon_beta/1'/> | |||
|} | |||
{{Clear}} | |||
<center> | |||
'''Synchronize the applets showing Interferons Alpha and Beta by clicking the checkbox''' | |||
<jmol> | |||
<jmolCheckbox> | |||
<target>A</target> | |||
<!--<scriptWhenChecked>set syncMouse ON;set syncScript OFF;sync jmolAppletB; sync > "set syncMouse | |||
ON;set syncScript OFF"</scriptWhenChecked>--> | |||
<scriptWhenChecked> sync jmolAppletB </scriptWhenChecked> | |||
<scriptWhenUnchecked> sync OFF</scriptWhenUnchecked> | |||
<text> Synchronize</text> | |||
</jmolCheckbox> | |||
</jmol> | |||
</center> | |||
== Other Treatments== | == Other Treatments== | ||
Revision as of 07:04, 9 April 2012
Please have patience as I edit this page over the next few weeks! Thank you!--Kirsten Eldredge 04:22, 9 April 2012 (IDT)
Interferon-βInterferon-β is a protein growth factor that stimulates an antiviral defense. Its encoding gene is one of only two known vertebrate structural genes that lacks introns.[1] Interferon-β is a relatively simple biological response modifier, with several . It consists of five , as well as multiple interconnecting , highlighted in blue. Helices A, B and D run , and helices C and E run to the other three helices, but to one another. Helix A consists of residues 6-23; Helix B consists of residues 49-65; Helix C consists of residues 77-91; Helix D consists of residues 112-131; and Helix E consists of residues 135-155.[2][3] Interferons alpha and beta interact with a receptor at the surface of [4] Interferon receptor
Interferon receptor bound to interferon alpha
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A comparative representation of the three forms of DNAA comparative representation of the three forms of DNA
Sources[6]
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Synchronize the applets showing Interferons Alpha and Beta by clicking the checkbox
Other TreatmentsOther Treatments
CopaxoneCopaxone
ReferencesReferences
- ↑ Voet, D., Voet, J.G., and C. Pratt. Fundamentals of Biochemistry 3rd Edition. Hoboken, NJ: John Wiley and Sons, 2008. Print.
- ↑ Kudo M. Management of hepatocellular carcinoma: from prevention to molecular targeted therapy. Oncology. 2010 Jul;78 Suppl 1:1-6. Epub 2010 Jul 8. PMID:20616576 doi:10.1159/000315222
- ↑ http://www.uniprot.org/uniprot/P00784
- ↑ [1] Samuel, C.E. "Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Inteferon Regulatory Factors." J Biol Chem 2007 282: 20045-20046. First Published on May 14, 2007, doi:10.1074/jbc.R700025200
- ↑ Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J. The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. Structure. 2003 Jul;11(7):791-802. PMID:12842042
- ↑ http://203.129.231.23/indira/nacc/
Relevant 3D StructuresRelevant 3D Structures
Interferon BetaInterferon Beta
1au1 - Homo sapiens
Interferon ReceptorsInterferon Receptors
3s98, 3se3, 3se4, 1n6u, 1n6v, 2hym, 2kz1, 2lag, 3s8w, 3s9d - Homo sapiens