1j2e: Difference between revisions
New page: left|200px<br /> <applet load="1j2e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j2e, resolution 2.6Å" /> '''Crystal structure of... |
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'''Crystal structure of Human Dipeptidyl peptidase IV'''<br /> | '''Crystal structure of Human Dipeptidyl peptidase IV'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1J2E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http:// | 1J2E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2E OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:04:52 2008'' | ||
Revision as of 17:04, 15 February 2008
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Crystal structure of Human Dipeptidyl peptidase IV
OverviewOverview
Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the, prolyl oligopeptidase (POP) family, and has been implicated in several, diseases. Therefore, the development of DPPIV selective inhibitors, which, are able to control the biological function of DPPIV, is important. We, determined the crystal structure of human DPPIV at 2.6A resolution. The, molecule consists of a unique eight-bladed beta-propeller domain in the, N-terminal region and a serine protease domain in the C-terminal region., Also, the large "cave" structure, which is thought to control the access, of the substrate, is found on the side of the beta-propeller fold., Comparison of the overall amino acid sequence between human DPPIV and POP, shows low homology (12.9%). In this paper, we report the structure of, human DPPIV, especially focusing on a unique eight-bladed beta-propeller, domain. We also discuss the way for the access of the substrate to this, domain.
About this StructureAbout this Structure
1J2E is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.
ReferenceReference
The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold., Hiramatsu H, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Yamamoto A, Shimizu R, Biochem Biophys Res Commun. 2003 Mar 21;302(4):849-54. PMID:12646248
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