1ipb: Difference between revisions
New page: left|200px<br /> <applet load="1ipb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ipb, resolution 2.0Å" /> '''CRYSTAL STRUCTURE OF... |
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[[Image:1ipb. | [[Image:1ipb.jpg|left|200px]]<br /><applet load="1ipb" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1ipb, resolution 2.0Å" /> | caption="1ipb, resolution 2.0Å" /> | ||
'''CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GPPPA'''<br /> | '''CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GPPPA'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1IPB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GTA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1IPB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GTA:'>GTA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IPB OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: protein biosynthesis]] | [[Category: protein biosynthesis]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:03:09 2008'' | ||
Revision as of 17:03, 15 February 2008
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CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GPPPA
OverviewOverview
The crystal structures of the full-length human eukaryotic initiation, factor (eIF) 4E complexed with two mRNA cap analogues [7-methylguanosine, 5'-triphosphate (m(7)GTP) and, P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)] were, determined at 2.0 A resolution (where 1 A=0.1 nm). The flexibility of the, C-terminal loop region of eIF4E complexed with m(7)GTP was significantly, reduced when complexed with m(7)GpppA, suggesting the importance of the, second nucleotide in the mRNA cap structure for the biological function of, eIF4E, especially the fixation and orientation of the C-terminal loop, region, including the eIF4E phosphorylation residue. The present results, provide the structural basis for the biological function of both N- and, C-terminal mobile regions of eIF4E in translation initiation, especially, the regulatory function through the switch-on/off of eIF4E-binding, protein-eIF4E phosphorylation.
About this StructureAbout this Structure
1IPB is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region., Tomoo K, Shen X, Okabe K, Nozoe Y, Fukuhara S, Morino S, Ishida T, Taniguchi T, Hasegawa H, Terashima A, Sasaki M, Katsuya Y, Kitamura K, Miyoshi H, Ishikawa M, Miura K, Biochem J. 2002 Mar 15;362(Pt 3):539-44. PMID:11879179
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