2ng1: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
2NG1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]] with GDP, DIO and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2NG1 OCA]]. | 2NG1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]] with GDP, DIO and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: I, II, III and IV. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2NG1 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: srp]] | [[Category: srp]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:05:03 2007'' | ||
Revision as of 14:00, 30 October 2007
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N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS
OverviewOverview
Ffh is a component of a bacterial ribonucleoprotein complex homologous to, the signal recognition particle (SRP) of eukaryotes. It comprises three, domains that mediate both binding to the hydrophobic signal sequence of, the nascent polypeptide and the GTP-dependent interaction of Ffh with a, structurally homologous GTPase of the SRP receptor. The X-ray structures, of the two-domain 'NG' GTPase of Ffh in complex with Mg2+GDP and GDP have, been determined at 2.0 A resolution. The structures explain the low, nucleotide affinity of Ffh and locate two regions of structural mobility, at opposite sides of the nucleotide-binding site. One of these regions, includes highly conserved sequence motifs that presumably contribute to, the structural trigger signaling the GTP-bound state. The other ... [(full description)]
About this StructureAbout this Structure
2NG1 is a [Single protein] structure of sequence from [Thermus aquaticus] with GDP, DIO and EDO as [ligands]. Structure known Active Sites: I, II, III and IV. Full crystallographic information is available from [OCA].
ReferenceReference
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP., Freymann DM, Keenan RJ, Stroud RM, Walter P, Nat Struct Biol. 1999 Aug;6(8):793-801. PMID:10426959
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