Cellular retinoic acid-binding protein: Difference between revisions
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Cellular Retinoic Acid Binding Proteins('''CRABPs''') are small intracellular proteins (15.5 | '''Cellular Retinoic Acid Binding Proteins'''('''CRABPs''') are small intracellular proteins (15.5 | ||
kDa) that belong to the family of intracellular lipid binding proteins (iLBP) which bind | kDa) that belong to the family of intracellular lipid binding proteins (iLBP) which bind | ||
small hydrophobic ligands. There are two types of CRABPs, CRABP I and CRABP II. They seem to play a role in controlling Retinoic Acid(RA)-mediated differentiation and proliferation processes [http://www.ncbi.nlm.nih.gov/pubmed/8756459?dopt=Abstract/]. During embryonic development, the spatial and temporal expression of the CRABP gene appears to be strictly regulated [http://www.ncbi.nlm.nih.gov/pubmed/2547683]. Therefore, it has been suggested that CRABP could be involved in the formation of gradients of RA across various developing tissues. Although the structure of CRABP I is similar to the cellular retinol-binding proteins, it binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. | small hydrophobic ligands. There are two types of CRABPs, CRABP I and CRABP II. They seem to play a role in controlling Retinoic Acid(RA)-mediated differentiation and proliferation processes [http://www.ncbi.nlm.nih.gov/pubmed/8756459?dopt=Abstract/]. During embryonic development, the spatial and temporal expression of the CRABP gene appears to be strictly regulated [http://www.ncbi.nlm.nih.gov/pubmed/2547683]. Therefore, it has been suggested that CRABP could be involved in the formation of gradients of RA across various developing tissues. Although the structure of CRABP I is similar to the cellular retinol-binding proteins, it binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. '''Epididymal RABP (ERABP)''' is an androgen-dependent RABP present in the lumen of the epididymis believed to be involved in sperm maturation. ERABP binds specifically all-trans- and 9-cis-RA. | ||
==Structure== | ==Structure== | ||
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[[3fep]] - hCRABP II (mutant) + ligand | [[3fep]] - hCRABP II (mutant) + ligand | ||
===ERABP=== | |||
[[1epa]] – rERABP – rat<br /> | |||
[[1epb]] – rERABP + RA | |||
==References== | ==References== | ||