1gtr: Difference between revisions
New page: left|200px<br /> <applet load="1gtr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gtr, resolution 2.5Å" /> '''STRUCTURAL BASIS OF ... |
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'''STRUCTURAL BASIS OF ANTICODON LOOP RECOGNITION BY GLUTAMINYL-TRNA SYNTHETASE'''<br /> | '''STRUCTURAL BASIS OF ANTICODON LOOP RECOGNITION BY GLUTAMINYL-TRNA SYNTHETASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1GTR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with ATP as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1GTR with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb16_1.html Aminoacyl-tRNA Synthetases]]. Active as [http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] Full crystallographic information is available from [http:// | 1GTR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1GTR with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb16_1.html Aminoacyl-tRNA Synthetases]]. Active as [http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GTR OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: complex (ligase/trna)]] | [[Category: complex (ligase/trna)]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:54:48 2008'' | ||
Revision as of 16:54, 15 February 2008
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STRUCTURAL BASIS OF ANTICODON LOOP RECOGNITION BY GLUTAMINYL-TRNA SYNTHETASE
OverviewOverview
The refined crystal structure of Escherichia coli glutaminyl transfer RNA, synthetase complexed with transfer RNA(Gln) and ATP reveals that the, structure of the anticodon loop of the enzyme-bound tRNA(Gln) differs, extensively from that of the known crystal structures of uncomplexed tRNA, molecules. The anticodon stem is extended by two non-Watson-Crick base, pairs, leaving the three anti-codon bases unpaired and splayed out to bind, snugly into three separate complementary pockets in the protein. These, interactions suggest that the entire anticodon loop provides essential, sites for glutaminyl tRNA synthetase discrimination among tRNA molecules.
About this StructureAbout this Structure
1GTR is a Single protein structure of sequence from Escherichia coli with as ligand. The following page contains interesting information on the relation of 1GTR with [Aminoacyl-tRNA Synthetases]. Active as Glutamine--tRNA ligase, with EC number 6.1.1.18 Full crystallographic information is available from OCA.
ReferenceReference
Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase., Rould MA, Perona JJ, Steitz TA, Nature. 1991 Jul 18;352(6332):213-8. PMID:1857417
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