1f4y: Difference between revisions
New page: left|200px<br /> <applet load="1f4y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f4y, resolution 2.8Å" /> '''CRYSTAL STRUCTURE OF... |
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[[Image:1f4y. | [[Image:1f4y.jpg|left|200px]]<br /><applet load="1f4y" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1f4y, resolution 2.8Å" /> | caption="1f4y, resolution 2.8Å" /> | ||
'''CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN'''<br /> | '''CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1F4Y is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with MGU as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1F4Y is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=MGU:'>MGU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F4Y OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: anti-carbohydrate antibody]] | [[Category: anti-carbohydrate antibody]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:45:54 2008'' | ||
Revision as of 16:45, 15 February 2008
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CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN
OverviewOverview
The crystal structure of the murine Fab S-20-4 from a protective, anti-cholera Ab specific for the lipopolysaccharide Ag of the Ogawa, serotype has been determined in its unliganded form and in complex with, synthetic fragments of the Ogawa O-specific polysaccharide (O-SP). The, upstream terminal O-SP monosaccharide is shown to be the primary antigenic, determinant. Additional perosamine residues protrude outwards from the Ab, surface and contribute only marginally to the binding affinity and, specificity. A complementary water-excluding hydrophobic interface and, five Ab-Ag hydrogen bonds are crucial for carbohydrate recognition. The, structure reported here explains the serotype specificity of anti-Ogawa, Abs and provides a rational basis toward the development of a synthetic, carbohydrate-based anti-cholera vaccine.
About this StructureAbout this Structure
1F4Y is a Protein complex structure of sequences from Mus musculus with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity., Villeneuve S, Souchon H, Riottot MM, Mazie JC, Lei P, Glaudemans CP, Kovac P, Fournier JM, Alzari PM, Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8433-8. PMID:10880560
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