3rik: Difference between revisions
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[[Image:3rik.jpg|left|200px]] | |||
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{{STRUCTURE_3rik| PDB=3rik | SCENE= }} | |||
===The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease=== | |||
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{{ABSTRACT_PUBMED_22047104}} | |||
==About this Structure== | |||
[[3rik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIK OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:022047104</ref><references group="xtra"/> | |||
[[Category: Glucosylceramidase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Lieberman, R L.]] | |||
[[Category: Orwig, S D.]] | |||
[[Category: Glycosylation]] | |||
[[Category: Hydrolase]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Lysosomal hydrolase]] | |||
[[Category: Lysosome]] | |||
[[Category: Tim-barrel]] | |||
Revision as of 09:38, 14 March 2012
The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher diseaseThe acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease
Template:ABSTRACT PUBMED 22047104
About this StructureAbout this Structure
3rik is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Orwig SD, Tan YL, Grimster NP, Yu Z, Powers ET, Kelly JW, Lieberman RL. Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease. Biochemistry. 2011 Dec 13;50(49):10647-57. Epub 2011 Nov 14. PMID:22047104 doi:10.1021/bi201619z