1e0a: Difference between revisions
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'''CDC42 COMPLEXED WITH THE GTPASE BINDING DOMAIN OF P21 ACTIVATED KINASE'''<br /> | '''CDC42 COMPLEXED WITH THE GTPASE BINDING DOMAIN OF P21 ACTIVATED KINASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1E0A is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with MG and GNP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1E0A is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GNP:'>GNP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0A OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: g protein signalling ser/thr kinase]] | [[Category: g protein signalling ser/thr kinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:41:11 2008'' | ||
Revision as of 16:41, 15 February 2008
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CDC42 COMPLEXED WITH THE GTPASE BINDING DOMAIN OF P21 ACTIVATED KINASE
OverviewOverview
The Rho family GTPases, Cdc42, Rac and Rho, regulate signal transduction, pathways via interactions with downstream effector proteins. We report, here the solution structure of Cdc42 bound to the GTPase binding domain of, alphaPAK, an effector of both Cdc42 and Rac. The structure is compared, with those of Cdc42 bound to similar fragments of ACK and WASP, two, effector proteins that bind only to Cdc42. The N-termini of all three, effector fragments bind in an extended conformation to strand beta2 of, Cdc42, and contact helices alpha1 and alpha5. The remaining residues bind, to switches I and II of Cdc42, but in a significantly different manner., The structure, together with mutagenesis data, suggests reasons for the, specificity of these interactions and provides insight into the mechanism, of PAK activation.
About this StructureAbout this Structure
1E0A is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus with and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Structure of Cdc42 bound to the GTPase binding domain of PAK., Morreale A, Venkatesan M, Mott HR, Owen D, Nietlispach D, Lowe PN, Laue ED, Nat Struct Biol. 2000 May;7(5):384-8. PMID:10802735
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