1dfg: Difference between revisions
New page: left|200px<br /> <applet load="1dfg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dfg, resolution 2.5Å" /> '''X-RAY STRUCTURE OF E... |
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[[Image:1dfg. | [[Image:1dfg.jpg|left|200px]]<br /><applet load="1dfg" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1dfg, resolution 2.5Å" /> | caption="1dfg, resolution 2.5Å" /> | ||
'''X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD AND BENZO-DIAZABORINE'''<br /> | '''X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD AND BENZO-DIAZABORINE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1DFG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with NAD and NDT as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1DFG with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb90_1.html Fatty Acid Synthase]]. Active as [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] Full crystallographic information is available from [http:// | 1DFG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=NAD:'>NAD</scene> and <scene name='pdbligand=NDT:'>NDT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1DFG with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb90_1.html Fatty Acid Synthase]]. Active as [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFG OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:39:38 2008'' | ||
Revision as of 16:39, 15 February 2008
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X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD AND BENZO-DIAZABORINE
OverviewOverview
Enoyl reductase (ENR), an enzyme involved in fatty acid biosynthesis, is, the target for antibacterial diazaborines and the front-line, antituberculosis drug isoniazid. Analysis of the structures of complexes, of Escherichia coli ENR with nicotinamide adenine dinucleotide and either, thienodiazaborine or benzodiazaborine revealed the formation of a covalent, bond between the 2' hydroxyl of the nicotinamide ribose and a boron atom, in the drugs to generate a tight, noncovalently bound bisubstrate analog., This analysis has implications for the structure-based design of, inhibitors of ENR, and similarities to other oxidoreductases suggest that, mimicking this molecular linkage may have generic applications in other, areas of medicinal chemistry.
About this StructureAbout this Structure
1DFG is a Single protein structure of sequence from Escherichia coli with and as ligands. The following page contains interesting information on the relation of 1DFG with [Fatty Acid Synthase]. Active as [acyl-carrier-protein_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number 1.3.1.9 Full crystallographic information is available from OCA.
ReferenceReference
A mechanism of drug action revealed by structural studies of enoyl reductase., Baldock C, Rafferty JB, Sedelnikova SE, Baker PJ, Stuitje AR, Slabas AR, Hawkes TR, Rice DW, Science. 1996 Dec 20;274(5295):2107-10. PMID:8953047 [[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
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