1cks: Difference between revisions
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'''HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL'''<br /> | '''HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1CKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1CKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKS OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: cell division]] | [[Category: cell division]] | ||
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Revision as of 16:36, 15 February 2008
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HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL
OverviewOverview
The cell cycle regulatory protein CksHs2 binds to the catalytic subunit of, the cyclin-dependent kinases (Cdk's) and is essential for their biological, function. The crystal structure of the protein was determined at 2.1 A, resolution. The CksHs2 structure is an unexpected hexamer formed by the, symmetric assembly of three interlocked dimers into an unusual 12-stranded, beta barrel fold that may represent a prototype for this class of protein, structures. Sequence-conserved regions form the unusual beta strand, exchange between the subunits of the dimer, and the metal and anion, binding sites associated with the hexamer assembly. The two other, sequence-conserved regions line a 12 A diameter tunnel through the beta, barrel and form the six exposed, charged helix pairs. Six kinase subunits, can be modeled to bind the assembled hexamer without collision, and, therefore this CksHs2 hexamer may participate in cell cycle control by, acting as the hub for Cdk multimerization in vivo.
About this StructureAbout this Structure
1CKS is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control., Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA, Science. 1993 Oct 15;262(5132):387-95. PMID:8211159
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