1bt6: Difference between revisions
New page: left|200px<br /> <applet load="1bt6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bt6, resolution 2.4Å" /> '''P11 (S100A10), LIGAN... |
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[[Image:1bt6. | [[Image:1bt6.jpg|left|200px]]<br /><applet load="1bt6" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1bt6, resolution 2.4Å" /> | caption="1bt6, resolution 2.4Å" /> | ||
'''P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS'''<br /> | '''P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1BT6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ACE as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1BT6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ACE:'>ACE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BT6 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: s100 family]] | [[Category: s100 family]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:33:21 2008'' | ||
Revision as of 16:33, 15 February 2008
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P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS
OverviewOverview
The aggregation and membrane fusion properties of annexin II are modulated, by the association with a regulatory light chain called p11.p11 is a, member of the S100 EF-hand protein family, which is unique in having lost, its calcium-binding properties. We report the first structure of a complex, between p11 and its cognate peptide, the N-terminus of annexin II, as well, as that of p11 alone. The basic unit for p11 is a tight, non-covalent, dimer. In the complex, each annexin II peptide forms hydrophobic, interactions with both p11 monomers, thus providing a structural basis for, high affinity interactions between an S100 protein and its target, sequence. Finally, p11 forms a disulfide-linked tetramer in both types of, crystals thus suggesting a model for an oxidized form of other S100, proteins that have been found in the extracellular milieu.
About this StructureAbout this Structure
1BT6 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of a complex of p11 with the annexin II N-terminal peptide., Rety S, Sopkova J, Renouard M, Osterloh D, Gerke V, Tabaries S, Russo-Marie F, Lewit-Bentley A, Nat Struct Biol. 1999 Jan;6(1):89-95. PMID:9886297
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