Interleukin-1 receptor-associated kinase: Difference between revisions
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[[2oid]] - hIRAK4 kinase domain + AMPPNP<br /> | [[2oid]] - hIRAK4 kinase domain + AMPPNP<br /> | ||
[[3mop]] - hIRAK4 DEATH domain + hIRAK2 DEATH domain + MYD88 | [[3mop]] - hIRAK4 DEATH domain + hIRAK2 DEATH domain + MYD88 | ||
[[Category:Topic Page]] | |||
Revision as of 13:44, 7 March 2012
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins. IRAK4 is involved in early recognition of pathogens and the initiation of inflammation when fighting infection. IRAK4 deficiency is a disorder which causes recurrent bacterial infections.
3D structures of IRAK43D structures of IRAK4
2nru, 2nry, 2oib, 2o8y – hIRAK4 kinase domain - human
1wh4 – mIRAK4 DEATH domain – mouse – NMR
2a9i - mIRAK4 DEATH domain
2oic - hIRAK4 kinase domain + staurosporine
2oid - hIRAK4 kinase domain + AMPPNP
3mop - hIRAK4 DEATH domain + hIRAK2 DEATH domain + MYD88