RNase A Oligomers: Difference between revisions
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[[Image:2D_RNaseA.png|300px|left|thumb|RNase A minor dimer, [[1a2w]]]] | [[Image:2D_RNaseA.png|300px|left|thumb|RNase A minor dimer, [[1a2w]]]] | ||
Bovine pancreatic ribonuclease A [http://en.wikipedia.org/wiki/Ribonuclease_A (RNase A)] is an enzyme that catalyzes the hydrolysis of RNA through [http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_193 acid-base catalysis]. RNase A has the capability to structurally form dimers, trimers, tetramers, and pentamers based on the structure of the [http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_192 RNase A monomer]. Though there are many oligomers, the three-dimensional structure for only the major dimer, minor dimer, and minor trimer are known. Unlike the monomers, all the oligomers are capable of catalyzing the hydrolysis of double stranded RNA (dsRNA).<ref name="tumor">PMID:12697760</ref> The oligomers are formed by 3D domain swapping, which can occur once or twice per monomeric unit <ref name="liul">PMID:11224563</ref >. The 3D domain swapping has no impact on the formation of active sites which is the same in the monomers and all oligomers.<ref name="liul"/> The oligomers of RNase A also show medical relevance as antitumor drugs as models to understand the possible cause of Alzheimer's. | Bovine pancreatic ribonuclease A [http://en.wikipedia.org/wiki/Ribonuclease_A (RNase A)] is an enzyme that catalyzes the hydrolysis of RNA through [http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_193 acid-base catalysis]. RNase A has the capability to structurally form dimers, trimers, tetramers, and pentamers based on the structure of the [http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_192 RNase A monomer]. Though there are many oligomers, the three-dimensional structure for only the major dimer, minor dimer, and minor trimer are known. Unlike the monomers, all the oligomers are capable of catalyzing the hydrolysis of double stranded RNA (dsRNA).<ref name="tumor">PMID:12697760</ref> The oligomers are formed by 3D domain swapping, which can occur once or twice per monomeric unit <ref name="liul">PMID:11224563</ref >. The 3D domain swapping has no impact on the formation of active sites which is the same in the monomers and all oligomers.<ref name="liul"/> The oligomers of RNase A also show medical relevance as antitumor drugs as models to understand the possible cause of Alzheimer's. | ||