1at3: Difference between revisions
New page: left|200px<br /> <applet load="1at3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1at3, resolution 2.5Å" /> '''HERPES SIMPLEX VIRUS... |
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==About this Structure== | ==About this Structure== | ||
1AT3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | 1AT3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]] with DFP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: ACT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AT3 OCA]]. | ||
==Reference== | ==Reference== | ||
Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex., Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS, Biochemistry. 1997 Nov 18;36(46):14023-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9369473 9369473] | Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex., Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS, Biochemistry. 1997 Nov 18;36(46):14023-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9369473 9369473] | ||
[[Category: Human herpesvirus | [[Category: Human herpesvirus 1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Abdel-Meguid, S.S.]] | [[Category: Abdel-Meguid, S.S.]] | ||
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[[Category: viral protease]] | [[Category: viral protease]] | ||
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Revision as of 13:54, 30 October 2007
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HERPES SIMPLEX VIRUS TYPE II PROTEASE
OverviewOverview
Human herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are, responsible for herpes labialis (cold sores) and genital herpes, respectively. They encode a serine protease that is required for viral, replication, and represent a viable target for therapeutic intervention., Here, we report the crystal structures of HSV-1 and HSV-2 proteases, the, latter in the presence and absence of the covalently bound transition, state analog inhibitor diisopropyl phosphate (DIP). The HSV-1 and HSV-2, protease structures show a fold that is neither like chymotrypsin nor like, subtilisin, and has been seen only in the recently determined, cytomegalovirus (CMV) and varicella-zoster virus (VZV) protease, structures. HSV-1 and HSV-2 proteases share high sequence homology and, have almost identical ... [(full description)]
About this StructureAbout this Structure
1AT3 is a [Single protein] structure of sequence from [Human herpesvirus 1] with DFP as [ligand]. Structure known Active Site: ACT. Full crystallographic information is available from [OCA].
ReferenceReference
Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex., Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS, Biochemistry. 1997 Nov 18;36(46):14023-9. PMID:9369473
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