1ad5: Difference between revisions
New page: left|200px<br /> <applet load="1ad5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ad5, resolution 2.6Å" /> '''SRC FAMILY KINASE HC... |
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[[Image:1ad5. | [[Image:1ad5.jpg|left|200px]]<br /><applet load="1ad5" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1ad5, resolution 2.6Å" /> | caption="1ad5, resolution 2.6Å" /> | ||
'''SRC FAMILY KINASE HCK-AMP-PNP COMPLEX'''<br /> | '''SRC FAMILY KINASE HCK-AMP-PNP COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1AD5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and ANP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http:// | 1AD5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ANP:'>ANP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AD5 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:28:40 2008'' | ||
Revision as of 16:28, 15 February 2008
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SRC FAMILY KINASE HCK-AMP-PNP COMPLEX
OverviewOverview
The crystal structure of the haematopoietic cell kinase Hck has been, determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a, consequence of intramolecular interactions of the enzyme's Src-homology, domains SH2 and SH3, with concomitant displacement of elements of the, catalytic domain. The conformation of the active site has similarities, with that of inactive cyclin-dependent protein kinases.
About this StructureAbout this Structure
1AD5 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658
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