2ix5: Difference between revisions
New page: left|200px<br /> <applet load="2ix5" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ix5, resolution 2.70Å" /> '''SHORT CHAIN SPECIFI... |
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==About this Structure== | ==About this Structure== | ||
2IX5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]] with CAA and FAD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.6 1.3.3.6]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IX5 OCA]]. | 2IX5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]] with CAA and FAD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Acyl-CoA_oxidase Acyl-CoA oxidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.6 1.3.3.6]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IX5 OCA]]. | ||
==Reference== | ==Reference== | ||
Controlling electron transfer in Acyl-CoA oxidases and dehydrogenases: a structural view., Mackenzie J, Pedersen L, Arent S, Henriksen A, J Biol Chem. 2006 Oct 13;281(41):31012-20. Epub 2006 Aug 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16887802 16887802] | Controlling electron transfer in Acyl-CoA oxidases and dehydrogenases: a structural view., Mackenzie J, Pedersen L, Arent S, Henriksen A, J Biol Chem. 2006 Oct 13;281(41):31012-20. Epub 2006 Aug 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16887802 16887802] | ||
[[Category: Acyl-CoA oxidase]] | |||
[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: peroxisome]] | [[Category: peroxisome]] | ||
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Revision as of 13:52, 30 October 2007
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SHORT CHAIN SPECIFIC ACYL-COA OXIDASE FROM ARABIDOPSIS THALIANA, ACX4 IN COMPLEX WITH ACETOACETYL-COA
OverviewOverview
Plants produce a unique peroxisomal short chain-specific acyl-CoA oxidase, (ACX4) for beta-oxidation of lipids. The short chain-specific oxidase has, little resemblance to other peroxisomal acyl-CoA oxidases but has an, approximately 30% sequence identity to mitochondrial acyl-CoA, dehydrogenases. Two biochemical features have been linked to structural, properties by comparing the structures of short chain-specific Arabidopsis, thaliana ACX4 with and without a substrate analogue bound in the active, site to known acyl-CoA oxidases and dehydrogenase structures: (i) a, solvent-accessible acyl binding pocket is not required for oxygen, reactivity, and (ii) the oligomeric state plays a role in substrate pocket, architecture but is not linked to oxygen reactivity. The structures, indicate that ... [(full description)]
About this StructureAbout this Structure
2IX5 is a [Single protein] structure of sequence from [Arabidopsis thaliana] with CAA and FAD as [ligands]. Active as [Acyl-CoA oxidase], with EC number [1.3.3.6]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Controlling electron transfer in Acyl-CoA oxidases and dehydrogenases: a structural view., Mackenzie J, Pedersen L, Arent S, Henriksen A, J Biol Chem. 2006 Oct 13;281(41):31012-20. Epub 2006 Aug 3. PMID:16887802
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