2ix0: Difference between revisions
New page: left|200px<br /> <applet load="2ix0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ix0, resolution 2.44Å" /> '''RNASE II'''<br /> ... |
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==About this Structure== | ==About this Structure== | ||
2IX0 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with MG, CA and C5P as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.1 3.1.13.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IX0 OCA]]. | 2IX0 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with MG, CA and C5P as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Exoribonuclease_II Exoribonuclease II]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.1 3.1.13.1]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IX0 OCA]]. | ||
==Reference== | ==Reference== | ||
Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex., Frazao C, McVey CE, Amblar M, Barbas A, Vonrhein C, Arraiano CM, Carrondo MA, Nature. 2006 Sep 7;443(7107):110-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16957732 16957732] | Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex., Frazao C, McVey CE, Amblar M, Barbas A, Vonrhein C, Arraiano CM, Carrondo MA, Nature. 2006 Sep 7;443(7107):110-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16957732 16957732] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Exoribonuclease II]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Amblar, M.]] | [[Category: Amblar, M.]] | ||
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[[Category: s1]] | [[Category: s1]] | ||
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Revision as of 13:52, 30 October 2007
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RNASE II
OverviewOverview
RNA degradation is a determining factor in the control of gene expression., The maturation, turnover and quality control of RNA is performed by many, different classes of ribonucleases. Ribonuclease II (RNase II) is a major, exoribonuclease that intervenes in all of these fundamental processes; it, can act independently or as a component of the exosome, an essential, RNA-degrading multiprotein complex. RNase II-like enzymes are found in all, three kingdoms of life, but there are no structural data for any of the, proteins of this family. Here we report the X-ray crystallographic, structures of both the ligand-free (at 2.44 A resolution) and RNA-bound, (at 2.74 A resolution) forms of Escherichia coli RNase II. In contrast to, sequence predictions, the structures show that RNase II is ... [(full description)]
About this StructureAbout this Structure
2IX0 is a [Single protein] structure of sequence from [Escherichia coli] with MG, CA and C5P as [ligands]. Active as [Exoribonuclease II], with EC number [3.1.13.1]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex., Frazao C, McVey CE, Amblar M, Barbas A, Vonrhein C, Arraiano CM, Carrondo MA, Nature. 2006 Sep 7;443(7107):110-4. PMID:16957732
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