Plectin: Difference between revisions
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==3D structures of plectin== | ==3D structures of plectin== | ||
[[1mb8]] – hPCN actin-binding domain – human | [[1mb8]] – hPCN actin-binding domain – human<br /> | ||
[[1sh5]], [[1sh6]] - PCN actin-binding domain – mouse | [[1sh5]], [[1sh6]] - PCN actin-binding domain – mouse<br /> | ||
[[3pdy]], [[3pe0]] - hPCN plakin domain | [[3pdy]], [[3pe0]] - hPCN plakin domain<br /> | ||
[[2odu]], [[2odv]] – hPCN plakin domain (mutant) | [[2odu]], [[2odv]] – hPCN plakin domain (mutant)<br /> | ||
[[3f7p]] - hPCN actin-binding domain + integrin β4 residues 1126-1370 | [[3f7p]] - hPCN actin-binding domain + integrin β4 residues 1126-1370 | ||
<references/> | <references/> | ||
Revision as of 10:14, 8 February 2012
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Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure [1]. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3).
3D structures of plectin3D structures of plectin
1mb8 – hPCN actin-binding domain – human
1sh5, 1sh6 - PCN actin-binding domain – mouse
3pdy, 3pe0 - hPCN plakin domain
2odu, 2odv – hPCN plakin domain (mutant)
3f7p - hPCN actin-binding domain + integrin β4 residues 1126-1370