Plectin: Difference between revisions
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Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3). | '''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3). | ||
==3D structures of plectin== | |||
[[1mb8]] – hPCN actin-binding domain – human | |||
[[1sh5]], [[1sh6]] - PCN actin-binding domain – mouse | |||
[[3pdy]], [[3pe0]] - hPCN plakin domain | |||
[[2odu]], [[2odv]] – hPCN plakin domain (mutant) | |||
[[3f7p]] - hPCN actin-binding domain + integrin β4 residues 1126-1370 | |||
<references/> | <references/> | ||
Revision as of 10:13, 8 February 2012
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Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure [1]. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3).
3D structures of plectin3D structures of plectin
1mb8 – hPCN actin-binding domain – human 1sh5, 1sh6 - PCN actin-binding domain – mouse 3pdy, 3pe0 - hPCN plakin domain 2odu, 2odv – hPCN plakin domain (mutant) 3f7p - hPCN actin-binding domain + integrin β4 residues 1126-1370