2i6z: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
2I6Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CPT:'>CPT</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=DMS:'>DMS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6Z OCA]. | 2I6Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CPT:'>CPT</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=DMS:'>DMS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Known structural/functional Sites: <scene name='pdbsite=AC1:Cpt+Binding+Site+For+Residue+A+300'>AC1</scene>, <scene name='pdbsite=AC2:Cl+Binding+Site+For+Residue+A+500'>AC2</scene> and <scene name='pdbsite=AC3:Dms+Binding+Site+For+Residue+A+400'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6Z OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
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Revision as of 18:28, 6 February 2008
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X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme
OverviewOverview
The interactions of cisplatin and its analogues, transplatin, carboplatin, and oxaliplatin, with hen egg white lysozyme were analysed through ESI, mass spectrometry, and the resulting metallodrug-protein adducts, identified; the X-ray crystal structure of the cisplatin lysozyme, derivative, solved at 1.9 A resolution, reveals selective platination of, imidazole Nepsilon of His15.
About this StructureAbout this Structure
2I6Z is a Single protein structure of sequence from Gallus gallus with , and as ligands. Active as Lysozyme, with EC number 3.2.1.17 Known structural/functional Sites: , and . Full crystallographic information is available from OCA.
ReferenceReference
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme., Casini A, Mastrobuoni G, Temperini C, Gabbiani C, Francese S, Moneti G, Supuran CT, Scozzafava A, Messori L, Chem Commun (Camb). 2007 Jan 14;(2):156-8. Epub 2006 Oct 26. PMID:17180231
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