Plectin: Difference between revisions
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<Structure load='1sh6' size='500' frame='true' align='right' caption=' | <Structure load='1sh6' size='500' frame='true' align='right' caption='Mouse plectin actin-binding domain' scene='Mouse plectin actin-binding domain/><!-- | ||
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Revision as of 14:48, 7 February 2012
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Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure [1]. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3).