3e62: Difference between revisions

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[[Image:3e62.png|left|200px]]
[[Image:3e62.png|left|200px]]


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{{ABSTRACT_PUBMED_19019674}}
{{ABSTRACT_PUBMED_19019674}}
==Disease==
Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myelofibrosis, idiopathic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myeloproliferative disorder with erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Polycythemia vera OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Thrombocythemia, essential OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Budd-Chiari syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]]


==About this Structure==
==About this Structure==
3E62 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E62 OCA].  
[[3e62]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E62 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19019674</ref><references group="xtra"/>
<ref group="xtra">PMID:019019674</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Antonysamy, S.]]
[[Category: Hirst, G.]]
[[Category: Park, F.]]
[[Category: Park, F.]]
[[Category: Sprengeler, P.]]
[[Category: Stappenbeck, F.]]
[[Category: Steensma, R.]]
[[Category: Thompson, D A.]]
[[Category: Wilson, M.]]
[[Category: Wong, M.]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Chromosomal rearrangement]]
[[Category: Disease mutation]]
[[Category: Disease mutation]]
[[Category: Drug discovery]]
[[Category: Drug discovery]]
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Proto-oncogene]]
[[Category: Proto-oncogene]]
[[Category: Sh2 domain]]
[[Category: Sh2 domain]]
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:14:21 2009''

Revision as of 09:25, 1 February 2012

File:3e62.png

Template:STRUCTURE 3e62

Fragment based discovery of JAK-2 inhibitorsFragment based discovery of JAK-2 inhibitors

Template:ABSTRACT PUBMED 19019674

About this StructureAbout this Structure

3e62 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. Antonysamy S, Hirst G, Park F, Sprengeler P, Stappenbeck F, Steensma R, Wilson M, Wong M. Fragment-based discovery of JAK-2 inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):279-82. Epub 2008 Aug 22. PMID:19019674 doi:10.1016/j.bmcl.2008.08.064

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