1ofh: Difference between revisions
New page: left|200px<br /> <applet load="1ofh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ofh, resolution 2.50Å" /> '''ASYMMETRIC COMPLEX ... |
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==About this Structure== | ==About this Structure== | ||
1OFH is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]] with PO4, MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OFH OCA]]. | 1OFH is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]] with PO4, MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OFH OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
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Revision as of 13:48, 30 October 2007
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ASYMMETRIC COMPLEX BETWEEN HSLV AND I-DOMAIN DELETED HSLU (H. INFLUENZAE)
OverviewOverview
In the prokaryotic homolog of the eukaryotic proteasome, HslUV, the, "double donut" HslV protease is allosterically activated by HslU, an AAA, protein of the Clp/Hsp100 family consisting of three (amino-terminal, carboxy-terminal, and intermediate) domains. The intermediate domains of, HslU, which extend like tentacles from the hexameric ring formed by the, amino-terminal and carboxy-terminal domains, have been deleted; an, asymmetric HslU(DeltaI)(6)HslV(12) complex has been crystallized; and the, structure has been solved to 2.5A resolution, revealing an assembly in, which a HslU(DeltaI) hexamer binds one end of the HslV dodecamer. The, conformation of the protomers of the HslU(DeltaI)-complexed HslV hexamer, is similar to that in the symmetric wild-type HslUV complex, while the, ... [(full description)]
About this StructureAbout this Structure
1OFH is a [Protein complex] structure of sequences from [Haemophilus influenzae] with PO4, MG and ADP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structure and reactivity of an asymmetric complex between HslV and I-domain deleted HslU, a prokaryotic homolog of the eukaryotic proteasome., Kwon AR, Kessler BM, Overkleeft HS, McKay DB, J Mol Biol. 2003 Jul 4;330(2):185-95. PMID:12823960
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