Sandbox 215: Difference between revisions
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In the plasma, CETP plays an important role in the transport of cholesteryl esters from the atheroprotective high-density lipoproteins (HDL) to the atherogenic lower-density lipoproteins (LDL) and also mediates the transport of triglycerides from LDL to HDL. | In the plasma, CETP plays an important role in the transport of cholesteryl esters from the atheroprotective high-density lipoproteins (HDL) to the atherogenic lower-density lipoproteins (LDL) and also mediates the transport of triglycerides from LDL to HDL. | ||
Most of the time, CETP facilites homoexchange by exchanging a triglyceride for another triglyceride and a cholesteryl ester for a cholesteryl ester between lipoproteins. However CETP can also promotes heteroexchange. | Most of the time, CETP facilites homoexchange by exchanging a triglyceride for another triglyceride and a cholesteryl ester for a cholesteryl ester between lipoproteins. However, CETP can also promotes heteroexchange. | ||
The cristal structure of CETP, in complex with four bound lipid molecules at 2,1 Å resolution shows a long tunnel traversing the core of the molecule. This tunnel has two large openings allowing lipids access and each opening is plugged by an amphiphilic phosphatidylcholine. | The cristal structure of CETP, in complex with four bound lipid molecules at 2,1 Å resolution shows a long tunnel traversing the core of the molecule. This tunnel has two large openings allowing lipids access and each opening is plugged by an amphiphilic phosphatidylcholine. | ||