Sandbox 27: Difference between revisions
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* '''A C-terminal intracellular domain''' | * '''A C-terminal intracellular domain''' | ||
Full information about the LRD domain from : [http://www.hotthyroidology.com/editorial_175.html Hot Thyroidology Journal] <ref>B R Smith, J Sanders, J Furmaniak, The TSH receptor – a new cristal structure, Hot Thyroidology Journal, article n°175</ref> | Full information about the LRD domain from : [http://www.hotthyroidology.com/editorial_175.html Hot Thyroidology Journal] <ref> B R Smith, J Sanders, J Furmaniak, The TSH receptor – a new cristal structure, Hot Thyroidology Journal, article n°175</ref> | ||
One of models for the receptor’s activation explains that interactions between ectodomain and extracellular loops would inhibit the activity of serpentine domain in the absence of stimulation. But when TSH is binding to LRD, the ectodomain would have a change of conformation which activates the transduction of signal. | One of models for the receptor’s activation explains that interactions between ectodomain and extracellular loops would inhibit the activity of serpentine domain in the absence of stimulation. But when TSH is binding to LRD, the ectodomain would have a change of conformation which activates the transduction of signal. <ref> V Vlaeminck-Guillem, G Vassart et S Costagliola, Un modèle d’activation du récepteur de la TSH / A THS receptor activation model, M/S : médecine sciences, vol. 18, n° 12, 2002, p. 1184-1186. </ref> | ||
== Structure of the complexe TSHR – M22 == | == Structure of the complexe TSHR – M22 == | ||