Sandbox 27: Difference between revisions
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Full information about the LRD domain from : [http://www.hotthyroidology.com/editorial_175.html Hot Thyroidology Journal] <ref>B R Smith, J Sanders, J Furmaniak, The TSH receptor – a new cristal structure, Hot Thyroidology Journal, article n°175</ref> | Full information about the LRD domain from : [http://www.hotthyroidology.com/editorial_175.html Hot Thyroidology Journal] <ref>B R Smith, J Sanders, J Furmaniak, The TSH receptor – a new cristal structure, Hot Thyroidology Journal, article n°175</ref> | ||
One of models for the receptor’s activation explains that interactions between ectodomain and extracellular loops would inhibit the activity of serpentine domain in the absence of stimulation. But when | One of models for the receptor’s activation explains that interactions between ectodomain and extracellular loops would inhibit the activity of serpentine domain in the absence of stimulation. But when TSH is binding to LRD, the ectodomain would have a change of conformation which activates the transduction of signal. | ||
== Structure of the complexe TSHR – M22 == | == Structure of the complexe TSHR – M22 == | ||