Sandbox 208: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-<Structure load='3CPI' size='400' frame='true' align='right' caption='Rab-Guanosine biphosphate Dissociation Inhibitor' scene='Insert optional scene name here' />
+[[Image:Crystal structure of yeast Rab-GDI.jpg | 200 px | left]]
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 All Rabs undergo posttranslational modification by prenylation. Prenylation is essential for Rab function and membrane association but also for its binding to GDI.
-In most cases, this post-translationally modification consists in the attachment of geranylgeranyl lipid groups on two C terminal cysteines. Geranylgeranylation is catalyzed by the prenyltransferase, geranylgeranyltransferase type II (GGTrII), a heterodimer containing α- and β-subunits. GGTrII requires the activity of an accessory protein, Rab escort protein (REP). REP is able to bind newly synthesized Rabs and to mediate their delivery to GGTrII.
+In most cases, this post-translationally modification consists in the attachment of geranylgeranyl lipid groups on two C-terminus cysteines. Geranylgeranylation is catalyzed by the prenyltransferase, geranylgeranyltransferase type II (GGTrII), a heterodimer containing α- and β-subunits. GGTrII requires the activity of an accessory protein, Rab escort protein (REP). REP is able to bind newly synthesized Rabs and to mediate their delivery to GGTrII.
 *'''GDI versus REP'''