Sandbox 208: Difference between revisions
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Both REP and GDI are considered as Rab molecular chaperones. They have similar organization, in particular, their Rab binding interface which is well conserved. | Both REP and GDI are considered as Rab molecular chaperones. They have similar organization, in particular, their Rab binding interface which is well conserved. | ||
=Structure= | ==Structure== | ||
<StructureSection load='3cpi' size='400' side='right' caption='Structure of RabGDI (PDB entry [[3cpi]])' scene=''> | |||
==Overall structure== | ==Overall structure== | ||
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GDIs have functional specificity for a particular Rab. Both yeast and mammalians GDIs contains specific residues that contribute to the strength of their interaction with distinct Rab species. | GDIs have functional specificity for a particular Rab. Both yeast and mammalians GDIs contains specific residues that contribute to the strength of their interaction with distinct Rab species. | ||
</StructureSection> | |||
= Catalytic mechanism = | = Catalytic mechanism = | ||