1gp5: Difference between revisions
New page: left|200px<br /> <applet load="1gp5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gp5, resolution 2.2Å" /> '''ANTHOCYANIDIN SYNTHA... |
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==About this Structure== | ==About this Structure== | ||
1GP5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]] with FE, AKG, MES, DQH and DH2 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GP5 OCA]]. | 1GP5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]] with FE, AKG, MES, DQH and DH2 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: IRN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GP5 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: flavonoid biosynthesis]] | [[Category: flavonoid biosynthesis]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:47:19 2007'' | ||
Revision as of 13:42, 30 October 2007
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ANTHOCYANIDIN SYNTHASE FROM ARABIDOPSIS THALIANA COMPLEXED WITH TRANS-DIHYDROQUERCETIN
OverviewOverview
Flavonoids are common colorants in plants and have long-established, biomedicinal properties. Anthocyanidin synthase (ANS), a 2-oxoglutarate, iron-dependent oxygenase, catalyzes the penultimate step in the, biosynthesis of the anthocyanin class of flavonoids. The crystal structure, of ANS reveals a multicomponent active site containing metal, cosubstrate, and two molecules of a substrate analog (dihydroquercetin). An additional, structure obtained after 30 min exposure to dioxygen is consistent with, the oxidation of the dihydroquercetin to quercetin and the concomitant, decarboxylation of 2-oxoglutarate to succinate. Together with in vitro, studies, the crystal structures suggest a mechanism for ANS-catalyzed, anthocyanidin formation from the natural leucoanthocyanidin substrates, ... [(full description)]
About this StructureAbout this Structure
1GP5 is a [Single protein] structure of sequence from [Arabidopsis thaliana] with FE, AKG, MES, DQH and DH2 as [ligands]. Structure known Active Site: IRN. Full crystallographic information is available from [OCA].
ReferenceReference
Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana., Wilmouth RC, Turnbull JJ, Welford RW, Clifton IJ, Prescott AG, Schofield CJ, Structure. 2002 Jan;10(1):93-103. PMID:11796114
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