Epidermal Growth Factor Receptor: Difference between revisions
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Ten percent of lung cancers occur in patients who are deemed to be "never smokers" which are people who have smoked less than 100 cigarettes in lifetime (3). Therefore, a large number of people are affected by lung cancer without smoking, and this is quite important. What do these people have in common if they are not smoking cigarettes? A study showed that 75% of cancers with a mutation in EGFR were from these "never smokers" (3). This means that gefitinib and erlotinib are most likely going to be effective on people who have not smoked because there is a high correlation of them having these mutations in EGFR. Studying these mutations and what causes them could be the next step in understanding how to prevent these types of lung cancers. | Ten percent of lung cancers occur in patients who are deemed to be "never smokers" which are people who have smoked less than 100 cigarettes in lifetime (3). Therefore, a large number of people are affected by lung cancer without smoking, and this is quite important. What do these people have in common if they are not smoking cigarettes? A study showed that 75% of cancers with a mutation in EGFR were from these "never smokers" (3). This means that gefitinib and erlotinib are most likely going to be effective on people who have not smoked because there is a high correlation of them having these mutations in EGFR. Studying these mutations and what causes them could be the next step in understanding how to prevent these types of lung cancers. | ||
== 3D Structures of Epidermal Growth Factor Receptor == | == 3D Structures of Epidermal Growth Factor Receptor == | ||
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=== EGFR extracellular domain === | === EGFR extracellular domain === | ||
[[3ltf]] – DmEGFR extracellular domain+spitz protein – ''Drosophila melanogaster''<br /> | [[3ltf]] – DmEGFR extracellular domain+spitz protein – ''Drosophila melanogaster''<br /> | ||