Sandbox 300: Difference between revisions
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<Structure load='PDBREF' size='300' frame='true' align='right' caption='Staphylococcal protein A' scene='Insert optional scene name here' /> | <Structure load='PDBREF' size='300' frame='true' align='right' caption='Staphylococcal protein A' scene='Insert optional scene name here' /> | ||
Staphylococcal protein A is originally a component of the cell wall in over 90% of ''Staphylococcus aureus'' strains.This protein, which is also called immunoglobulin G binding protein A is covalently linked to the peptidoglycan of the cell wall. | Staphylococcal protein A is originally a component of the cell wall in over 90% of ''Staphylococcus aureus'' strains.<ref>Peterson, P. K., Verhoef, J., Sabath, L. D., & Quie, P. G. (1977). Effect of protein A on staphylococcal opsonization. Infection and immunity, 15(3), 760-4</ref> | ||
This protein, which is also called immunoglobulin G binding protein A is covalently linked to the peptidoglycan of the cell wall. | |||
Nowadays the protein is often used for biochemical analysis due to its structural and biochemical properties. | Nowadays the protein is often used for biochemical analysis due to its structural and biochemical properties. | ||
The expression of the chromosomal spa gene, which encodes the protein A, is regulated by the ''agr'' system and Rot. The level of expression is up-regulated by Rot and down-regulated by ''agr''. | The expression of the chromosomal spa gene, which encodes the protein A, is regulated by the ''agr'' system and Rot. The level of expression is up-regulated by Rot and down-regulated by ''agr''. | ||
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==References== | ==References== | ||
<references/> | |||