Proteasome: Difference between revisions
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[[Image:3gpt.jpg|left|200px|thumb|Crystal Structure of Proteasome, [[3gpt]]]] | [[Image:3gpt.jpg|left|200px|thumb|Crystal Structure of Proteasome, [[3gpt]]]] | ||
{{STRUCTURE_3gpt| PDB=3gpt | SIZE= | {{STRUCTURE_3gpt| PDB=3gpt | SIZE=400| SCENE= |right|CAPTION=Proteasome complex with salinosporamide derivative, [[3gpt]] }} | ||
[[Proteasome]] (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 | [[Proteasome]] (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 α subunits which form the PRTS gate. The two inner rings contain 6 β subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin. The images at the left and at the right correspond to one representative Proteasome, ''i.e.'' the crystal structure of yeast Proteasome ([[3gpt]]). | ||
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