2c3b: Difference between revisions
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[[Image:2c3b.gif|left|200px]]<br /><applet load="2c3b" size=" | [[Image:2c3b.gif|left|200px]]<br /><applet load="2c3b" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2c3b, resolution 1.85Å" /> | caption="2c3b, resolution 1.85Å" /> | ||
'''THE CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CYCLOPHILIN REVEALS 3D DOMAIN SWAPPING OF A CENTRAL ELEMENT'''<br /> | '''THE CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CYCLOPHILIN REVEALS 3D DOMAIN SWAPPING OF A CENTRAL ELEMENT'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2C3B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:So4 Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http:// | 2C3B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3B OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: rotamase]] | [[Category: rotamase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:30:54 2008'' | ||
Revision as of 11:30, 3 February 2008
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THE CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CYCLOPHILIN REVEALS 3D DOMAIN SWAPPING OF A CENTRAL ELEMENT
OverviewOverview
The crystal structure of Aspergillus fumigatus cyclophilin (Asp f 11) was, solved by the multiwavelength anomalous dispersion method and was refined, to a resolution of 1.85 A with R and R(free) values of 18.9% and 21.4%, respectively. Many cyclophilin structures have been solved to date, all, showing the same monomeric conformation. In contrast, the structure of A., fumigatus cyclophilin reveals dimerization by 3D domain swapping and, represents one of the first proteins with a swapped central domain. The, domain-swapped element consists of two beta strands and a subsequent loop, carrying a conserved tryptophan. The tryptophan binds into the active, site, inactivating cis-trans isomerization. This might be a means of, biological regulation. The two hinge loops leave the protein prone to, misfolding. In this context, alternative forms of 3D domain swapping that, can lead to N- or C-terminally swapped dimers, oligomers, and aggregates, are discussed.
About this StructureAbout this Structure
2C3B is a Single protein structure of sequence from Aspergillus fumigatus with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of Aspergillus fumigatus cyclophilin reveals 3D domain swapping of a central element., Limacher A, Kloer DP, Fluckiger S, Folkers G, Crameri R, Scapozza L, Structure. 2006 Feb;14(2):185-95. PMID:16472738
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