2c2u: Difference between revisions
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[[Image:2c2u.gif|left|200px]]<br /><applet load="2c2u" size=" | [[Image:2c2u.gif|left|200px]]<br /><applet load="2c2u" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2c2u, resolution 1.10Å" /> | caption="2c2u, resolution 1.10Å" /> | ||
'''DPS FROM DEINOCOCCUS RADIODURANS'''<br /> | '''DPS FROM DEINOCOCCUS RADIODURANS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2C2U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with SO4, ZN and FE as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Fe Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | 2C2U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=FE:'>FE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Fe+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2U OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: iron]] | [[Category: iron]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:30:44 2008'' | ||
Revision as of 11:30, 3 February 2008
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DPS FROM DEINOCOCCUS RADIODURANS
OverviewOverview
The crystal structure of a DNA-binding protein from starved cells (Dps), (DR2263) from Deinococcus radiodurans was determined in two states: a, native form, to 1.1-A resolution, and one soaked in an iron solution, to, 1.6-A resolution. In comparison with other Dps proteins, DR2263 has an, extended N-terminal extension, in both structures presented here, a novel, metal binding site was identified in this N-terminal extension and was, assigned to bound zinc. The zinc is tetrahedrally coordinated and the, ligands, that belong to the N-terminal extension, are two histidines, one, glutamate and one aspartate residue, which are unique to this protein, within the Dps family. In the iron-soaked crystal structure, a total of, three iron sites per monomer were found: one site corresponds to the, ferroxidase centre with structural similarities to those found in other, Dps family members; the two other sites are located on the two different, threefold axes corresponding to small pores in the Dps sphere, which may, possibly form the entrance and exit channels for iron storage.
About this StructureAbout this Structure
2C2U is a Single protein structure of sequence from Deinococcus radiodurans with , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of Deinococcus radiodurans Dps protein (DR2263) reveals the presence of a novel metal centre in the N terminus., Romao CV, Mitchell EP, McSweeney S, J Biol Inorg Chem. 2006 Oct;11(7):891-902. Epub 2006 Jul 20. PMID:16855817
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