Nucleoporin: Difference between revisions
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[[Image:1xip.png|left|200px|thumb|Crystal structure of the N-terminal domain of yeast Nucleoporin NUP159, [[1xip]]]] | [[Image:1xip.png|left|200px|thumb|Crystal structure of the N-terminal domain of yeast Nucleoporin NUP159, [[1xip]]]] | ||
{{STRUCTURE_1xip| PDB=1xip | SIZE=300| SCENE=Nucleoporin/Cv/1 |right|CAPTION=yeast Nucleoporin NUP159, [[1xip]] }} | {{STRUCTURE_1xip| PDB=1xip | SIZE=300| SCENE=Nucleoporin/Cv/1 |right|CAPTION=yeast Nucleoporin NUP159, [[1xip]] }} | ||
[[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD). The images at the left and at the right correspond to one representative Nucleoporin structure, ''i.e.'' crystal structure of yeast Nucleoporin NUP159 from ''Saccharomyces cerevisiae'' ([[1xip]]), | [[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD). The images at the left and at the right correspond to one representative Nucleoporin structure, ''i.e.'' crystal structure of yeast Nucleoporin NUP159 from ''Saccharomyces cerevisiae'' ([[1xip]]), | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
== 3D Structures of Nucleoporin == | == 3D Structures of Nucleoporin == | ||
''Updated December 2011'' | |||
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==NUP2== | ==NUP2== | ||
[[3n7c]] – NUP2 RANBD – ''Ashbya gossypii''<br /> | [[3n7c]] – NUP2 RANBD – ''Ashbya gossypii''<br /> | ||
[[2c1t]] – yNUP2 | [[2c1t]] – yNUP2 NTD +importrin alpha subunit - yeast<br /> | ||
==NUP35== | ==NUP35== | ||
[[1wwh]] – mNUP35 MPPN domain - mouse<br /> | [[1wwh]] – mNUP35 MPPN domain - mouse<br /> | ||
==NUP50== | ==NUP50== | ||
[[2ec1]] – hNUP50 RANBD - human<br /> | [[2ec1]] – hNUP50 RANBD - human<br /> | ||
[[2c1m]] – mNUP50 | [[2c1m]] – mNUP50 NTD +importin <br /> | ||
==NUP53== | ==NUP53== | ||
[[3p3d]] - NUP53 RRM domain - Pischia guillermondii | [[3p3d]] - NUP53 RRM domain - ''Pischia guillermondii'' | ||
==NUP54== | |||
[[3t97]] – rNUP54 + NUP62 - rat<br /> | |||
==NUP58== | ==NUP58== | ||
[[2osz]] – rNUP58/45 | [[2osz]] – rNUP58/45 <br /> | ||
==NUP82== | |||
[[3pbp]] – yNUP82 NTD + NUP116 CTD + NUP159 tail<br /> | |||
==NUP84== | ==NUP84== | ||
[[3jro]], [[3iko]] – yNUP84+NUP145+protein Sec13<br /> | [[3jro]], [[3iko]] – yNUP84+NUP145+protein Sec13<br /> | ||
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==NUP98== | ==NUP98== | ||
[[3mmy]] – hNUP98 fragment+mRNA export factor <br /> | [[3mmy]] – hNUP98 fragment+mRNA export factor <br /> | ||
[[2q5x]], [[2q5y]] – hNUP98 | [[2q5x]], [[2q5y]] – hNUP98 CTD<br /> | ||
[[1ko6]] – hNUP98 | [[1ko6]] – hNUP98 CTD<br /> | ||
==NUP100== | ==NUP100== | ||
[[3nf5]] – NUP100 | [[3nf5]] – NUP100 CTD – ''Candida glabrata''<br /> | ||
==NUP107== | ==NUP107== | ||
[[3i4r]], [[3cqc]], [[3cqg]] – hNUP107+NUP133<br /> | [[3i4r]], [[3cqc]], [[3cqg]] – hNUP107+NUP133<br /> | ||
==NUP116== | ==NUP116== | ||
[[2aiv]] – yNUP116 | [[2aiv]] – yNUP116 CTD - NMR<br /> | ||
==NUP120== | ==NUP120== | ||
[[3f7f]], [[3h7n]], [[3hxr]] – yNUP120<br /> | [[3f7f]], [[3h7n]], [[3hxr]] – yNUP120<br /> | ||
==NUP133== | ==NUP133== | ||
[[1xks]] – hNUP133 | [[1xks]] – hNUP133 NTD<br /> | ||
[[3kfo]] – yNUP133 | [[3kfo]] – yNUP133 CTD <br /> | ||
==NUP145== | ==NUP145== | ||
[[3bg0]], [[3bg1]] – hNUP145+Sec13-related protein<br /> | [[3bg0]], [[3bg1]] – hNUP145+Sec13-related protein<br /> | ||
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[[2k0c]] – rNUP153 RANBD – NMR<br /> | [[2k0c]] – rNUP153 RANBD – NMR<br /> | ||
==NUP159== | ==NUP159== | ||
[[1xip]] – yNUP159 | [[1xip]] – yNUP159 NTD<br /> | ||
[[3rrm]] – yNUP159 residues 2-387 + NUP Gle1 + IP6 + ADP<br /> | |||
==NUP170== | ==NUP170== | ||
[[3i5p]], [[3i5q]] – yNUP170<br /> | [[3i5p]], [[3i5q]] – yNUP170<br /> | ||
==NUP214== | ==NUP214== | ||
[[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br /> | [[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br /> | ||
[[2oit]] – hNUP214 | [[2oit]] – hNUP214 NTD<br /> | ||
==NUP358== | ==NUP358== | ||
[[1z5s]] – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN | [[1z5s]] – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN CTD<br /> | ||
[[1xke]] - hNUP358 RANBD - NMR<br /> | [[1xke]] - hNUP358 RANBD - NMR<br /> | ||
==NUP1P== | ==NUP1P== | ||
[[2bpt]] – yNUP1P+importin β subunit<br /> | [[2bpt]] – yNUP1P+importin β subunit<br /> | ||
==NUP2P== | ==NUP2P== | ||
[[1un0]] – yNUP2P | [[1un0]] – yNUP2P NTD+importrin α subunit<br /> | ||
==NUP-NSP1== | ==NUP-NSP1== | ||
[[1o6o]] – yNUP-NSP1 residues 497-608+importrin β subunit<br /> | [[1o6o]] – yNUP-NSP1 residues 497-608+importrin β subunit<br /> | ||
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[[2doq]], [[2gv5]] – yNUP-CDC31+SFI1P<br /> | [[2doq]], [[2gv5]] – yNUP-CDC31+SFI1P<br /> | ||
[[3fwb]], [[3fwc]] - yNUP-CDC31+SAC3<br /> | [[3fwb]], [[3fwc]] - yNUP-CDC31+SAC3<br /> | ||
==NUP Gle1== | |||
[[3peu]], [[3pev]], [[3rrn]]– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6 | |||
[[2rfo]], [[2qx5]] – yNic96<br /> | [[2rfo]], [[2qx5]] – yNic96<br /> | ||
[[1gyb]] – NUP+yNTF2<br /> | [[1gyb]] – NUP+yNTF2<br /> | ||