Nitric Oxide Synthase: Difference between revisions
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== Additional 3D Structures of Nitric Oxide Synthase == | == Additional 3D Structures of Nitric Oxide Synthase == | ||
'' | ''Updated December 2011'' | ||
'''Nitric Oxide Synthase''' (NOS) is an enzyme which catalyzes the production of the signaling molecule NO from arginine. In mammals, NOS appears as 3 isozymes: neuronal NOS (nNOS), cytokine-inducible NOS (iNOS) and endothelial NOS (eNOS). The N-terminal domain of NOS is an oxygenase domain (OD). NOS cofactors are: NADPH, FAD, FMN, heme and O2. <br /> | '''Nitric Oxide Synthase''' (NOS) is an enzyme which catalyzes the production of the signaling molecule NO from arginine. In mammals, NOS appears as 3 isozymes: neuronal NOS (nNOS), cytokine-inducible NOS (iNOS) and endothelial NOS (eNOS). The N-terminal domain of NOS is an oxygenase domain (OD). NOS cofactors are: NADPH, FAD, FMN, heme and O2. <br /> | ||
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===Endothelial NOS=== | ===Endothelial NOS=== | ||
[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]] – b-eNOS OD+pyrrolidinomethyl | [[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]] – b-eNOS OD+pyrrolidinomethyl pyridine derivative – bovine<br /> | ||
[[1dm6]] – b-eNOS OD+guanidine derivative<br /> | [[1dm6]] – b-eNOS OD+guanidine derivative<br /> | ||
[[3nlh]] – b-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br /> | [[3nlh]] – b-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br /> | ||
[[ | [[1rs8]], [[1rs9]], [[1p6n]] – b-eNOS OD +dipeptide inhibitor<br /> | ||
[[ | |||
[[1nse]] – b-eNOS OD<br /> | [[1nse]] – b-eNOS OD<br /> | ||
[[1p6n]] – b-eNOS OD +dipeptide inhibitor<br /> | [[1p6n]] – b-eNOS OD +dipeptide inhibitor<br /> | ||
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[[1i83]], [[1d1v]], [[1d1x]], [[1d1y]], [[1ed4]], [[9nse]] – b-eNOS OD+urea derivative<br /> | [[1i83]], [[1d1v]], [[1d1x]], [[1d1y]], [[1ed4]], [[9nse]] – b-eNOS OD+urea derivative<br /> | ||
[[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative<br /> | [[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative<br /> | ||
[[1foi]], [[1dmi]], [[1i83]], [[3n5p]], [[3n5q]], [[3n5r]], [[3n5s]], [[3n5t]], [[3n5v]], [[3n5w]], [[3n5x]], [[3n5y]], [[3n5z]], [[3n60]], [[3n61]], [[3n62]], [[3n63]], [[3n64]], [[3n65]], [[3n66]], [[3n67]], [[3n68]], [[3n69]], [[3n6a]], [[3n6b]], [[3n6c]], [[3n6d]], [[3n6e]], [[3n6f]], [[3n6g]], [[3nlt]], [[3nlu]] – b-eNOS OD+inhibitor<br /> | [[1foi]], [[1dmi]], [[1i83]], [[3n5p]], [[3n5q]], [[3n5r]], [[3n5s]], [[3n5t]], [[3n5v]], [[3n5w]], [[3n5x]], [[3n5y]], [[3n5z]], [[3n60]], [[3n61]], [[3n62]], [[3n63]], [[3n64]], [[3n65]], [[3n66]], [[3n67]], [[3n68]], [[3n69]], [[3n6a]], [[3n6b]], [[3n6c]], [[3n6d]], [[3n6e]], [[3n6f]], [[3n6g]], [[3nlt]], [[3nlu]], [[3e7s]] – b-eNOS OD+inhibitor<br /> | ||
[[1d0c]], [[8nse]], [[1foj]], [[1ed5]] – b-eNOS OD+indazole derivative<br /> | [[1d0c]], [[8nse]], [[1foj]], [[1ed5]], [[1d0o]], [[1d1w]] – b-eNOS OD+indazole derivative<br /> | ||
[[1dm8]] – b-eNOS OD+triazole derivative<br /> | [[1dm8]] – b-eNOS OD+triazole derivative<br /> | ||
[[1ed6]] – b-eNOS OD+NO<br /> | [[1ed6]] – b-eNOS OD+NO<br /> | ||
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[[1m9j]] – h-eNOS OD+chlorzoxazone<br /> | [[1m9j]] – h-eNOS OD+chlorzoxazone<br /> | ||
[[1m9k]], [[1m9r]] – h-eNOS OD+indazole derivative<br /> | [[1m9k]], [[1m9r]] – h-eNOS OD+indazole derivative<br /> | ||
[[1nsi]] - h-eNOS OD+ Zn | |||
===Neuronal NOS=== | ===Neuronal NOS=== | ||
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[[3nli]], [[3nlj]], [[3nlk]], [[3nln]], [[3nlo]], [[3nlp]], [[3nlq]], [[3nlr]], [[3jws]], [[3jwt]], [[3jwu]], [[3jwv]], [[3jx0]], [[3jx1]], [[3jx2]], [[3jx3]], [[3jx4]], [[3jx5]], [[3jx6]], [[3dqr]] – r-nNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative – rat<br /> | [[3nli]], [[3nlj]], [[3nlk]], [[3nln]], [[3nlo]], [[3nlp]], [[3nlq]], [[3nlr]], [[3jws]], [[3jwt]], [[3jwu]], [[3jwv]], [[3jx0]], [[3jx1]], [[3jx2]], [[3jx3]], [[3jx4]], [[3jx5]], [[3jx6]], [[3dqr]] – r-nNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative – rat<br /> | ||
[[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]] – r-nNOS OD+pyrrolidinomethyl aminopyridine derivative<br /> | [[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]] – r-nNOS OD+pyrrolidinomethyl aminopyridine derivative<br /> | ||
[[3pne]], [[3pnf]], [[3png]], [[3svp]], [[3svq]] – r-nNOS OD+pyrrolidinomethyl methylpyridine derivative<br /> | |||
[[2hx3]] – r-nNOS OD+nitroguanidine derivative<br /> | [[2hx3]] – r-nNOS OD+nitroguanidine derivative<br /> | ||
[[2hx4]], [[1zvl]] – r-nNOS OD+arginine derivative<br /> | [[2hx4]], [[1zvl]] – r-nNOS OD+arginine derivative<br /> | ||
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[[1lzz]], [[1m00]] – r-nNOS OD+guanidine derivative<br /> | [[1lzz]], [[1m00]] – r-nNOS OD+guanidine derivative<br /> | ||
[[3fc5]], [[1zvi]] – r-nNOS OD<br /> | [[3fc5]], [[1zvi]] – r-nNOS OD<br /> | ||
[[1qau]] - r-nNOS OD PDZ domain<br /> | |||
[[1qav]] - r-nNOS OD PDZ domain + α-1 syntrophin<br /> | |||
[[1qw6]] – r-nNOS OD+arginine derivative<br /> | [[1qw6]] – r-nNOS OD+arginine derivative<br /> | ||
[[1qwc]], [[3q99]], [[3q9a]] – r-nNOS OD+inhibitor<br /> | [[1qwc]], [[3q99]], [[3q9a]] – r-nNOS OD+inhibitor<br /> | ||
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===Inducible NOS=== | ===Inducible NOS=== | ||
[[3nqs]], [[3e65]] – m-iNOS OD + pterin derivative<br /> | [[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]] – m-iNOS OD + pterin derivative<br /> | ||
[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br /> | [[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br /> | ||
[[2bhj]] – m-iNOS OD+coumarin<br /> | [[2bhj]] – m-iNOS OD+coumarin<br /> | ||
[[3nod]] – m-iNOS OD+product analog<br /> | [[3nod]] – m-iNOS OD+product analog<br /> | ||
[[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase<br /> | [[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase<br /> | ||
[[3e67]] – m-iNOS OD+4-MAP<br /> | [[3e67]] – m-iNOS OD+4-MAP<br /> | ||
[[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]], [[2y37]] – m-iNOS OD+inhibitor <br /> | [[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]], [[2y37]] – m-iNOS OD+inhibitor <br /> | ||
[[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]] – m-iNOS OD+imidazole derivative<br /> | [[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]], [[3nw2]] – m-iNOS OD+imidazole derivative<br /> | ||
[[1df1]] - m-iNOS OD+ urea derivative<br /> | |||
[[3dwj]] – m-iNOS OD (mutant)<br /> | [[3dwj]] – m-iNOS OD (mutant)<br /> | ||
[[1qom]] - m-iNOS OD<br /> | |||
[[1qw4]], [[1dwv]], [[1dww]], [[1dwx]], [[1nod]] – m-iNOS OD+arginine derivative<br /> | [[1qw4]], [[1dwv]], [[1dww]], [[1dwx]], [[1nod]] – m-iNOS OD+arginine derivative<br /> | ||
[[2nos]] – m-iNOS OD+guanidine derivative<br /> | [[2nos]] – m-iNOS OD+guanidine derivative<br /> | ||