Sandbox Reserved 384: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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 ===Molecular Function===
-The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin.
+The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.
 ==Ongoing Research==