Human Caspase-1: Difference between revisions
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==Activation and Regulation== | ==Activation and Regulation== | ||
Caspase-1 begins as a proenzyme which is cleaved into 20kDa and 10kDa subunits. ASC and Ipaf have been identified as possible regulators of caspase-1 in a structure called the inflammasome. ASC leads to ATP-driven activation of caspase-1, while Ipaf connects signals triggered by intracellular pathogens. Both of these activators are | Caspase-1 begins as a proenzyme which is cleaved into 20kDa and 10kDa subunits. ASC and Ipaf have been identified as possible regulators of caspase-1 in a structure called the inflammasome. ASC leads to ATP-driven activation of caspase-1, while Ipaf connects signals triggered by intracellular pathogens.<ref name=Mariathasan>PMID:15190255</ref> Both of these activators are essential for caspase-1 driven cell death, showing a link between inflammation and apoptosis. Adaptors in the inflammasome react to extracellular and endogenous danger signals, usually flaggelin, to activate caspase-1 and begin the inflammatory response.<ref name=Franchi>PMID:19221555</ref> | ||
==Structure== | ==Structure== | ||