1w2k: Difference between revisions
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[[Image:1w2k.gif|left|200px]]<br /><applet load="1w2k" size=" | [[Image:1w2k.gif|left|200px]]<br /><applet load="1w2k" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1w2k, resolution 3.00Å" /> | caption="1w2k, resolution 3.00Å" /> | ||
'''TF7A_4380 COMPLEX'''<br /> | '''TF7A_4380 COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1W2K is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FUC, BGC, CA, CAC and 380 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Known structural/functional Site: <scene name='pdbsite=AC1:Bgc Binding Site For Chain L'>AC1</scene>. Full crystallographic information is available from [http:// | 1W2K is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FUC:'>FUC</scene>, <scene name='pdbligand=BGC:'>BGC</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CAC:'>CAC</scene> and <scene name='pdbligand=380:'>380</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Known structural/functional Site: <scene name='pdbsite=AC1:Bgc+Binding+Site+For+Chain+L'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2K OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: vitamin k]] | [[Category: vitamin k]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:18:30 2008'' | ||
Revision as of 11:18, 3 February 2008
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TF7A_4380 COMPLEX
OverviewOverview
Proof of concept experiments have shown that tissue factor/factor VIIa, inhibitors have antithrombotic activity without enhancing bleeding, propensity. Starting from lead compounds generated by a biased, combinatorial approach, phenylglycine amide tissue factor/factor VIIa, inhibitors with low nanomolar affinity and good selectivity against other, serine proteases of the coagulation cascade were designed, using the, guidance of X-ray structural analysis and molecular modelling.
DiseaseDisease
Known diseases associated with this structure: Esophageal squamous cell carcinoma OMIM:[606551], Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this StructureAbout this Structure
1W2K is a Protein complex structure of sequences from Homo sapiens with , , , and as ligands. Active as Coagulation factor VIIa, with EC number 3.4.21.21 Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Coagulation factor VIIa
- Homo sapiens
- Protein complex
- Ackermann, J.
- Arcy, A.D.
- Banner, D.W.
- Groebke-Zbinden, K.
- Ji, Y.
- Kirchhofer, D.
- Tschopp, T.B.
- Wallbaum, S.
- Weber, L.
- 380
- BGC
- CA
- CAC
- FUC
- Blood coagulation
- Calcium-binding
- Co-factor
- Coagulation
- Enzyme complex
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydrolase
- Plasma
- Serine protease
- Vitamin k