Shiga toxin: Difference between revisions
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==Structure== | ==Structure== | ||
Shiga Toxin consists consists of an | Shiga Toxin consists consists of an AB<sub>5</sub> hexamer.<ref name=Fraser>PMID: 7656009</ref> The | ||
<scene name='Shiga_toxin_1/Subunits/1'>5 subunit B pentamer interacts with the A subunit</scene> via a <scene name='Shiga_toxin_1/A-b_helixes/1'>C-terminal helix of hydrophobic subunits packed antiparallel to 5 B helixes</scene> and | <scene name='Shiga_toxin_1/Subunits/1'>5 subunit B pentamer interacts with the A subunit</scene> via a <scene name='Shiga_toxin_1/A-b_helixes/1'>C-terminal helix of hydrophobic subunits packed antiparallel to 5 B helixes</scene> and | ||
<scene name='Shiga_toxin_1/Beta_sheet/1'>4 antiparallel beta sheets</scene>.<ref name=Fraser>PMID: 7656009</ref>. The <scene name='Shiga_toxin_1/Active_site_zoomed_out_a-b/1'>glycosidase active site</scene> is located on the A subunit, but is blocked by the B subunit until they are cleaved and an active A subunit is released into the target cell.<ref name=Fraser>PMID: 7656009</ref> | <scene name='Shiga_toxin_1/Beta_sheet/1'>4 antiparallel beta sheets</scene>.<ref name=Fraser>PMID: 7656009</ref>. The <scene name='Shiga_toxin_1/Active_site_zoomed_out_a-b/1'>glycosidase active site</scene> is located on the A subunit, but is blocked by the B subunit until they are cleaved and an active A subunit is released into the target cell.<ref name=Fraser>PMID: 7656009</ref> | ||