1ahw: Difference between revisions
New page: left|200px<br /> <applet load="1ahw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ahw, resolution 3.00Å" /> '''A COMPLEX OF EXTRAC... |
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==About this Structure== | ==About this Structure== | ||
1AHW is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AHW OCA]]. | 1AHW is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]]. Structure known Active Sites: BSC and BSF. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AHW OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: tissue factor]] | [[Category: tissue factor]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:34:26 2007'' | ||
Revision as of 13:29, 30 October 2007
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A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9)
OverviewOverview
The tissue factor (TF)-initiated blood coagulation protease cascade can be, greatly inhibited in vivo by a potent anti-human-TF monoclonal antibody, 5G9. This antibody binds the carboxyl module of the extracellular domain, of TF with a nanomolar binding constant and inhibits the formation of the, TF.VIIa.X ternary initiation complex. We have determined the crystal, structures of the extra-cellular modules of human TF, Fab 5G9, and their, complex (TF.5G9) to 2.4 A, 2. 5 A, and 3.0 A, respectively, and measured, the apparent inhibition constants of 5G9 on a panel of TF mutants. In our, unliganded TF structure, a 7 degrees change in the relative orientation, between the D1 and D2 modules was observed when compared with other, published TF structures. Comparison of the free and bound Fab 5G9, ... [(full description)]
About this StructureAbout this Structure
1AHW is a [Protein complex] structure of sequences from [Homo sapiens] and [Mus musculus]. Structure known Active Sites: BSC and BSF. Full crystallographic information is available from [OCA].
ReferenceReference
The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex., Huang M, Syed R, Stura EA, Stone MJ, Stefanko RS, Ruf W, Edgington TS, Wilson IA, J Mol Biol. 1998 Feb 6;275(5):873-94. PMID:9480775
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