1a1r: Difference between revisions
New page: left|200px<br /> <applet load="1a1r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a1r, resolution 2.5Å" /> '''HCV NS3 PROTEASE DOM... |
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==About this Structure== | ==About this Structure== | ||
1A1R is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/ | 1A1R is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Gb_virus_c Gb virus c]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: AC1, AC2, ZN1 and ZN2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A1R OCA]]. | ||
==Reference== | ==Reference== | ||
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8861917 8861917] | Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8861917 8861917] | ||
[[Category: | [[Category: Gb virus c]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Caron, P.R.]] | [[Category: Caron, P.R.]] | ||
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[[Category: viral protein]] | [[Category: viral protein]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:33:53 2007'' | ||
Revision as of 13:29, 30 October 2007
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HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX
OverviewOverview
An estimated 1% of the global human population is infected by hepatitis C, viruses (HCVs), and there are no broadly effective treatments for the, debilitating progression of chronic hepatitis C. A serine protease located, within the HCV NS3 protein processes the viral polyprotein at four, specific sites and is considered essential for replication. Thus, it, emerges as an attractive target for drug design. We report here the 2.5, angstrom resolution X-ray crystal structure of the NS3 protease domain, complexed with a synthetic NS4A activator peptide. The protease has a, chymotrypsin-like fold and features a tetrahedrally coordinated metal ion, distal to the active site. The NS4A peptide intercalates within a beta, sheet of the enzyme core.
About this StructureAbout this Structure
1A1R is a [Protein complex] structure of sequences from [Gb virus c] with ZN as [ligand]. Structure known Active Sites: AC1, AC2, ZN1 and ZN2. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:8861917
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Gb virus c
- Protein complex
- Caron, P.R.
- Chambers, S.P.
- Dwyer, M.D.
- Fox, T.
- Harbeson, S.L.
- Kim, J.L.
- Landro, J.A.
- Lepre, C.A.
- Lin, C.
- Malley, E.T.O.
- Markland, W.
- Morgenstern, K.A.
- Murcko, M.A.
- Rice, C.M.
- Thomson, J.A.
- ZN
- Cofactor peptide
- Helicase
- Nonstructural proteins
- Serine protease
- Viral protein